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大鼠心肌缺血及再灌时血浆蛋白C的变化 被引量:4

The Change of Plasma Protein C in Ischemic Reperfused Myocardium in Rat
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摘要 复制大鼠心肌缺血再灌模型,观察血浆抗凝因子蛋白C(PC)的活性变化及血浆PAI和t-PA的活性,同时监测心电图、血清LDH、SGOT和心脏病理学改变。结果表明,心肌缺血时PC活性明显降低(与对照组比P<0.05),随着缺血时间延长,PC活性呈现进一步下降。此外,t-PA活性的变化规律与PC相同,PAI则与PC相反。缺血再灌后PC、t-PA和PAI活性都略有恢夏。提示,PC活性降低参与急性心肌梗塞(AMI)过程,与心肌损伤程度有关;PC与t-PA、PAI之间存在着协调作用。PC缺乏可能与AMI发病有关系。 he change of plasma protein C (PC)activity was studied in the experimentalAMI of rat. On the other hand,t- PA and PAI activity were observed in thismodel at the same time. The results showed that plasma PC activity was decreased sigificantly in myocardial ischemia as compared to control(P<0.05,I.vs C).Decrease of PCactivity had negative relation with ischemic time. The change of t-PA activitywas similar to that of PC in ischemia. PAI change was contrary to PC. PC、t- PAand PAI activity were recovered slightly after ischemia reperfusion. These suggestedthat decrease of PC activity may be involve in AMI. PG was concerted with t-PAand PAI in this pathological state.
出处 《基础医学与临床》 CSCD 1994年第5期52-55,共4页 Basic and Clinical Medicine
基金 中华医学基金奖学金
关键词 血浆 心肌梗塞 心肌缺血 再灌注 protein C(PC)acute myoardial infarction(AMI)ischemia reperfusion tissue type plasminogen activator( t-PA ) plasminogen activitor (PAI)
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