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滇产胡椒属植物9301醇提物抗血小板活化因子作用的研究 被引量:2

Studies on the Anti-PAF Effect of Alcohol Extract of Piper Sp. Native to Yunnan
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摘要 本文以血小板活化因子(PAF)诱导的兔血小板聚集,大鼠足肿胀和离体平滑肌收缩为指标观察了9301对PAF活性的影响,结果表明:9301醇提物不仅能抑制PAF诱导的兔血小板聚集和大鼠足肿胀,而且能抑制PAF引起的离体大鼠和豚鼠回肠平滑肌收缩,提示9301醇提物具有较强的抗PAF作用. latelet activating factorPAF)is a potent lipid mediator relating to anaphylaxis andinflammation. In this paper,the effects of the alcohol extract of a Chinese herbal plant,PiperSp. 930I native to Yunnan on PAF activities were reported.The extract of Piper Sp.930l markedly inhibited rabbit platelet aggregation induced byPAF and arachidonic acid(AA)in vitro(IC50:160.5 and 239.8 mg·L-1respecytively),and PAF一induced rat hindpaw edema in vivo(600 mg·kg-1p,o).Meanwhile,it was ob-served the extract suppressed the sustained contraction of both isolated rat and guinea pigileum not only induced by PAF,but also by acetylcholine(Ach),K+and histmine(Hist).These results indicate that the extract of Piper sp. has a potent anti一PAF action.
出处 《昆明医学院学报》 1994年第3期22-25,共4页 Journal of Kunming Medical College
基金 云南省应用基础研究基金
关键词 胡椒属 血小板活化因子 Piper SP. Platelet activating factor Platelet aggregatio Rat hindpaw edema Smooth一muscle contraction
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