不对称合成Ⅲ:以天然产物(十)一樟脑为手征性助剂对映选择合成(R)-α-氨基酸

ASYMMETRIC SYNTHESIS Ⅲ:ENANTIOSELETIVE SYNTHESIS OF (R)-α-AMINO ACIDS USING THE NATURAL PRODUCT(+)-CAMPHOR AS CHIRAL AUXILIARY REAGENT

本文以(十)—樟脑为手征性助剂,通过樟脑酮亚胺(3)的不对称烷基化反应,对映选择合成3(R)-a-氨基酸,其光学产率为71—95%,这是一种立体控制刑成碳-碳键的新合成体系。

The enantioselective synthesis of (R)-α-amino acids via asymmetric alkylation of the chiral ketimine using (+)-camphor as chiral auxiliary reagent has been achieved. The optical yields of obtained (R)-a-amino acids are 71—95%.It is a new system for the stereocontrolled carbon-carbon bond formation.