多种肿瘤标志物联合检测在食管癌早期诊断中的价值

To Evaluate the Combined Detection of Multiple Tumor Markers in Early Diagnosis of Esophageal Cancer

【目的】为探讨肿瘤标志物联合检测在食管癌诊断中的临床意义。【方法】分别用酶免法 (ELISA)、手工测定了92例食管癌及30例非肿瘤患者的8种血清肿瘤标志物,应用特异性、敏感性、阳性预 期值(HPV)、阴性预期值(NPV)、准确率等指标综合评价各种肿瘤标志物的临床应用价值。【结果】8种肿瘤 标志物中,NES、CYFRA21 1、CA72 4联合检测的敏感性为79.22%,特异性为83.21%,准确性为78.64%。 【结论】NES、CYFRA21 1、CA72 4联合检测对食管癌诊断有实用价值。

ObjectiveTo explore the clinical value of combined detection of multiple tumor markers in early diagnosis of esophageal cancer (EC).Eight kinds of serum tumor markers in 92 patients with EC and 30 non-tumor patients were detected by enzyme linked immunosorbent assay (ELISA ) and manual estimation respectively. The specificity sensitivity, positive expectant value (PEV), negative expectant value(NEV) and rate of accuracy were used to make a comprehensive evaluation of these tumor markers for their clinical significance. The best 3 out of 8 kinds of tumor markers were NES、CYFRA21-1 and CA72-4.The sensitivity of their combined detection was 79.22% , their specificity was 83.21%, with an accuracy of 78.64%.[Conclusion]Combined detection of NES,CYFRA21-1 and CA72-4 shows practical value in the diagnosis of EC.