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健脾降浊方对脾虚型高脂血症大鼠脂质代谢影响的实验研究 被引量:11

Experimental Study of Jianpi Jiangzhuo Recipe on Effect of the Blood-lipid Metabolism of Rats with the Spleen-asthenia Hyperlipidemia
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摘要 目的:从探讨健脾降浊方对脾虚型高脂血症大鼠脂质代谢的影响。方法:建立脾虚型高脂血症大鼠模型,以健脾降浊方治疗为治疗组,以血脂康、绞股蓝治疗作为对照组,观察治疗后血清总脂质、载脂蛋白A、载脂蛋白B、脂蛋白(a)的变化,并进行组间比较。结果:健脾降浊方不同剂量能不同程度降低高脂血症模型大鼠的血清总脂质、载脂蛋白B、脂蛋白(a)含量、升高血清载脂蛋白A的含量(P均<0.01),其中大、中剂量组与血脂康对照组疗效相仿(P>0.05),而优于绞股蓝对照组(P<0.05~0.01)。结论:健脾降浊方能有效改善脾虚型高脂血症大鼠的脂质代谢,从动物实验角度初步证明从脾论治高脂血症的可行性。 Objective:This study inquires into the feasibility of treating hyperlipidemia on the basis of the spleen by animal experiment. Methods:The hyperlipidemia animal model of Spleen-asthenia is made by Wistar rats. The effect of Jianpijiangzhuofang upon the serum total lipid, apolipoprotein A, apolipoprotein B and lipoprotein(a) is observed and contrasted with Xuezhikang and Fiveleaf gynostemma herb. The comparison among groups is implemented. Results:Jianpijiangzhuofang of different dosage groups can reduce the amount of the serum total lipid, apolipoprotein B and lipoprotein(a), and increase the amount of apolipoprotein A to variable degrees of model rats (P<0.01 in both cases). The curative effect of the massive and the small dose groups are similar to the control group of Xuezhikang (P >0.05) but is better than the control group of Fiveleaf gynostemma herb (P<0.05~0.01).Conclusion:This study proves that Jianpijiangzhuofang has good effect of the blood-lipid metabolism. This study also proves initially feasibility of treating hyperlipidemia on the basis of the spleen by animal experiment.
出处 《湖北中医学院学报》 2005年第1期7-10,共4页 Journal of Hubei College of Traditional Chinese Medicine
关键词 健脾降浊方 高脂血症 脾虚 痰浊 实验研究 中医药疗法 Jianpijiangzhuofang hyperlipidemia Spleen-asthenia Turbidphlegm Experimental study
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