sCD_(44V6)检测对非小细胞肺癌的临床意义

Clinical significance of detecting serum sCD_(44V6) in non-small cell lung carcinoma

目的探讨血清CD44V6(sCD44V6)对非小细胞肺癌的临床意义。方法用ELISA法检测42例非小细胞肺癌患者及30名正常人sCD44V6浓度。结果正常人sCD44V6浓度显著低于非小细胞肺癌患者(P<0.01)。鳞癌与腺癌患者sCD44V6浓度差异无显著性。sCD44V6对非小细胞肺癌诊断有较高的敏感性和特异性。结论CD44V6是一较好的非小细胞肺癌肿瘤标志物,能在一定程度上提高非小细胞肺癌的早期诊断率。

Objective To explore the clinical significance of detecting serum sCD44V6 in non?- small cell lung carcinoma. Methods Levels of serum sCD44V6 in 42 patients with lung carcinoma and in 30 healthy persons were measured by ELISA. Results There was obvious difference of serum sCD44V6 levels between patients with lung carcinoma and healthy persons. There was no difference between patients with squamous cell carcinoma and with adenocarcinoma. sCD44V6 have the higher positive rate and specificity. Conclusions sCD44V6 would be a good way to non?- small cell lung carcinoma, and could be useful to the diagnosis of early?- stage non?- small cell lung carcinoma.