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^(99)mTc-HL91和Tl-201双核素心肌显像在冠心病中的初步临床研究 被引量:2

A preliminary clinical study of dual isotope imaging of ^(99)mTc-HL91 and T1-201 in coronary artery diseases
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摘要 目的探索^(99)mTc-HL91乏氧心肌显像在冠心病中的可行性及临床应用价值。方法3例急性心肌梗塞,1例不稳定性心绞痛连续病例行Tl-201和99mTc-HL91双核素心肌显像,比较两种核素心肌显像、阳性节段数以及匹配方式。结果99mTc-HL91可以提供较清晰的乏氧心肌图像并用于心肌节段分析;3例急性心肌梗塞,1例不稳定性心绞痛患者共68个节段,Tl-201判断为阳性节段23个,占34%;99mTc-HL91判断为阳性节段36个,占53%;24小时Tl-201延迟显像显示为可逆性分布7个节段,99mTc-HL91均呈阳性显像;99mTc-HL91比Tl-201多判断出13个阳性节段,占19%。双核素心肌显像有4种匹配方式:Tl-201正常/99mTc-HL91无显像,25个节段;Tl-201正常/99mTc-HL91显像,20个节段;Tl-201异常/99mTc-HL91显像,16个节段;Tl-201异常/99mTc-HL91无显像,7个节段。即刻Tl-201显像示23个异常节段,其中16个节段呈99mTc-HL91阳性显像,占70%,24小时Tl-201延迟显像显示有7个(部分)可逆性节段,占30%,99mTc-HL91检测缺血/存活心肌的能力显著高于Tl-201(P=0.008)。结论99mTc-HL91可以用于冠心病的心肌乏氧成像并用于心肌节段分析,乏氧显像为研究冠心病提供了新的手段。尚需大样本的临床研究。 Objective To explore the feasibility of hypoxia imaging of myocardium tissues and its clinical values in coronary artery disease patients with 99mTc-HL91. Methods 3 acute myocardial infarction(AMI) and 1 unstable angina pectoris(UA) consecutive patients underwent dual isotope imaging of Tl-201 and 99mTc-HL91, and two kinds of myocardial imaging, positive myocardial segments and matching ways were compared. Results 99mTc-HL91 had provided pretty discernible hypoxia imaging of myocardial tissues in AMI and UA patients for further myocardial segment analysis. There had been 23 positive segments by Tl-201, taking up 34% while there had been 36 positive segments by 99mTc-HL91, taking up 53%, with additional 13 positive segments estimated by 99mTc-HL91, taking up 19%. There have been 7 reversible segments on 24h-Tl-201 delayed imaging, which were also manifest on 99mTc-HL91 hypoxia imaging. Dual isotope imaging of Tl-201 and 99mTc-HL91 includes 4 matching ways: normal Tl-201 imaging/negative 99mTc-HL91imaging, with 25 segments;normal Tl-201 imaging /positive 99mTc-HL91imaging,with 20 segments;abnormal Tl-201 imaging/ positive 99mTc-HL91 imaging,with 16 segments;abnormal Tl-201 imaging / negative 99mTc-HL91 imaging,with 7 segments. There were 7 (partially) reversible segments (ischemic/viable segments) on 24-hour-delayed-Tl-201 imaging and 16 positive segments on 99mTc-HL91 imaging among 156 abnormal segments based on immediate Tl-201 imaging, in which the 40 (partially) reversible segments were all positive of hypoxia imaging. The Tl-201 detection rate was 30%, and the 99mTc-HL91, 70%, with the latter being significantly higher than the former(P=0.008). Conclusion A new imaging method with hypoxic tracer of 99mTc-HL91 has been introduced and its potential clinical values have been manifest on the basis of this preliminary study. Large scale studies are warranted.
出处 《中国现代医药杂志》 2005年第1期6-9,共4页 Modern Medicine Journal of China
基金 江苏省135重点人才资助项目(编号No.200319)
关键词 ^99MTC-HL91 Tl-201 双核素 心肌显像 冠心病 铊-201 心肌乏氧成像 mTc-HL91 Tl-201 Coronary artery diseases Hypoxia
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