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盐酸小檗碱的调脂作用的研究 被引量:62

Research on the effective improvement of hyperlipidemia by berberine
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摘要 目的 探讨盐酸小檗碱(BBR)的降脂作用和作用机制。 方法 68 例混合型高脂血症患者分为盐酸小檗硷(BBR)组34例及他汀类降脂药对照组34例(舒降之16 例、立普妥 18 例),分别选用BBR 0.5 g日3次、立普妥10 mg日1次、舒降之20 mg日 1 次。疗程 8 周,比较治疗前后血脂的变化。同时,以RT PCR和 Western杂交法检测人外周血和肝细胞的低密度脂蛋白受体(LD LR)、过氧化物酶体增殖物激活受体γ的mRNA表达。 结果 BBR组治疗后总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL C)分别下降 21.41%、26.4%、28.22%,治疗前后比较差异有统计学意义(P= 0.000), TC下降较舒降之组更明显(P= 0.001), TG 的下降优于立普妥组(P=0 026),治疗后LDL-C下降和高密度脂蛋白胆固醇升高的疗效与对照组等同。 结论 BBR有良好的调脂作用,某些方面可能较他汀类降脂药更具有优势。其调脂机制与促进细胞 LDLR-mRNA转录,增强LDLR蛋白的表达,介导细胞对脂蛋白的摄取和代谢相关,是一种廉价、高效、安全的调脂药。 Objective To investigate the therapeutic effect of berberine (BBR) on regulating hyperlipidemia and its possible mechanism. Methods Sixty eight patients with hyperlipidemia were divided into two groups according to the method of treatment: BBR (n=34), simvastatin(n=16)and atorvastain (n=18). Plasma levels of TC,TG,LDL-C and HDL-C were measured before and after therapy. At the same time, expression of LDLR and PPARγ mRNA were analyzed with RT-PCR and Western blot. Results The plasma TC,TG and LDL-C levels decreased by 21.41% , 26.4% and 28.22% respectively , and there were significant differences before and after BBR treatment (P=0.000). The plasma TC level of BBR group was significantly lower than that of simvastatin group (P=0.001). and the plasma TG level of BBR group was lowers than that of atorvastain group. There were the same changes in the plasma LDL-C and HDL-C levels among BBR, simvastatin and atorvastain groups. Berberine accelerated LDLR mRNA transcription, up-regulated LDLR expression and regulated cellular absorption and metabolism of lipid protein. Conclusions Berberine has effective role in lowering plasma TC, TG and LDL-C levels, which may be superior to simvastatin and atorvastain in some aspects. The mechanism of its lowering blood lipid is related to its effect on LDLR expression.
出处 《中华糖尿病杂志(1006-6187)》 CSCD 北大核心 2005年第1期49-51,共3页
基金 国家自然科学基金资助项目(30271527)
关键词 调脂作用 舒降之 盐酸小檗碱 治疗后 治疗前后 LDL-C 立普妥 对照组 他汀类降脂药 TC Berberine Receptor, LDL Hyperlipemia Peroxisomes
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  • 1Rubinstein LV,Shoemaker RH,Paull KD, et al. Comparison of in vitro anticancer-durg-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines. J Natl Cancer Inst,1990,82:1113-1118.
  • 2Hui KK,Yu JL,Chan WF, et al. Interaction of berberine with human platelet alpha 2 adrenoceptors. Life Sci, 1991,49: 315-324.
  • 3Chi CW, Chang YF, Chao TW, et al. Flowcytometric analysis of the effect of berberine on the expression of glucocorticoid receptors in human hepatoma HepG2 cells. Life Sci, 1994,54:2099-107.

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