抗真菌肽对真菌作用机制研究进展

Advance in The Research of The Function of Antifungal Peptides Against Fungus

20世纪90年代初,Iijima等从麻蝇幼虫血淋巴分离出一种具有抗真菌活性、能抑制C.albicans生长的蛋白质. 到目前为止,已发现150多种肽具有抗真菌的特性,随着被发现的抗真菌肽数目不断增多,人们对抗真菌肽的抗真菌机理也进行了大量的研究,抗真菌肽对真菌的作用方式主要有:阻止、破坏真菌细胞壁的合成;与膜作用,在质膜上形成孔洞,使重要的内容物外泄;与真菌细胞内线粒体、核酸大分子等重要细胞器相互作用;最终导致真菌的死亡.

In the early 1990's, Iijima et al. separated a protein, which has the activity of antifungal to suppress the growth of C.albicans, from the hemp musca larva blood lymph. So far, more than 150 kinds of peptides which are characteristic of antifungal have been discovered. With the number of antifungal peptides discovered increasing, researchers have been studying the mechanism of antifungal peptides. The way the antifungal peptides function is mainly as follows: preventing and damaging the synthesis of cell wall; interacting with the membrane to form pores; causing the important inclusions to release; interacting with the important organelles such as mitochondrion and nucleic acid macromolecules in the fungi cell, leading to the death.