复发性口疮SOD和细胞免疫功能改变及意义

Changes of SOD and Cellular lmmunity in Recurrent Aphthous Ulcer

目的 探讨超氧化物歧化酶 (superoxidedismutase, SOD)和细胞免疫功能改变在复发性口疮发病中的作用。方法 选择复发性口疮患者 54例,健康成人 (健康对照组 ) 40例作对照研究,分别取静脉血测定SOD活性和间接免疫荧光法检测T细胞亚群。结果 复发性口疮患者的SOD活性明显低于健康对照组,差异有显著性(P<0. 05);而T淋巴细胞亚群也有改变,CD3、CD4 和CD4 /CD8 比值明显低于正常对照组,差异有显著性(P<0. 05),CD8 高于正常对照组,差异也有显著性(P<0. 05)。结论 SOD活性和细胞免疫功能在复发性口疮患者中明显低下,二者在其发病机理中起着一定作用。

Objective To explore the roles of superoxide dismutase(SOD) and cellular immunity in recurrent aphthous ulcer(RAU) . Methods The venous bloods were collected from 54 RAU patients and 40 adult healthy persons,the SOD were investigated by xanthine oxidase method;and indirect immunofluorescence detect T lymphocyte subsets.Results The activity of SOD in RAU group was lower than the control group,there was a significant difference(P<0.05);T lymphocyte subsets also changed, CD 3、CD 4and CD 4/CD 8 decreased(P<0.05) and CD 8 increased significantly (P<0.05) .Conclusion SOD and cellular immunity take an important role in the RAU.