胃癌患者血浆可溶性血管内皮细胞生长因子的检测及其意义

Significance of detecting soluable serum vascular endothelial growth factor in gastric cancer patients

目的 :应用定量ELISA法检测胃癌患者血浆可溶性血管内皮细胞生长因子 (VEGF)的水平 ,并探讨其临床意义。方法 :采用定量酶联免疫吸附试验双抗体夹心法检测 3 2例胃癌患者和 2 0例正常对照人群的血浆可溶性VEGF水平。结果 :血浆可溶性VEGF水平胃癌患者显著高于正常对照人群 ,分化程度较差、有区域淋巴结转移和远处转移的胃癌患者显著高于分化程度较好、没有区域淋巴结转移和远处转移的患者。结论 :血浆可溶性VEGF浓度对于预测胃癌的侵袭和转移可能具有重要临床意义。

Objective To investigate the level of soluable serum vascular endothelial growth factor (VEGF) in patients with gastric cancer by quantitative enzyme-linked immunosorbent assay (ELISA),and to evaluate its clinical significance.Method 32 patients with gastric cancer and 20 normal controls were selected to detect the soluable serum VEGF by quantitative ELISA.Results The soluable serum VEGF in patients with gastric cancer was significant higher than that of normal controls,the VEGF levels in patients with undifferentiated gastric cancer and focal lymph node and distant metastasis were significant higher than those of patients with well differentiated gastric cancer and without focal lymph node and distance metastasis.Conclusion Soluable serum VEGF concentration is a significant predictive factor in gastric cancer invasion and metastasis.