成人肝移植术后肺部并发症回顾分析

Retrospective Study on the Postoperative Respiratory Complications in Adult Liver Transplant Recipients

目的 探讨成人肝移植术后早期 (3个月内 )肺部并发症的种类、发生率及原因。方法 回顾性分析 4 9例肝移植术后与肺部并发症 (胸腔积液、肺部感染、肺水肿、肺不张和急性呼吸功能衰竭 )发生可能的相关因素。结果 在肝移植术后早期有 34例患者合并肺部并发症 ,发生率为 6 9.4 %。最常见为胸腔积液 (n =2 6 ,5 3.1% ) ,其后依次为肺部感染 (n =8,16 .3% )、肺不张 (n =6 ,12 .3% )、急性呼吸功能衰竭 (n =5 ,10 .2 % )、肺水肿 (n =2 ,4 .1% )。与未发生肺部并发症的病例相比 ,发生者组的死亡率明显偏高 (P =0 .0 4 8) ,术后拔除气管插管的时间明显延长 (P =0 .0 4 2 ) ,术后第 1天的凝血功能较差 (P =0 .0 2 3)。并发胸腔积液的患者仅 3例需行引流术 ,其他均自愈。结论 采取有效措施减少危险因素 。

Purpose To explore the types,the incidence,and the causes of early postoperative (<3 months) respiratory complications in adult liver transplant (LT) recipients. Methods We reviewed the data of 49 consecutive adult LT recipients.Pulmonary atelectasis,pleural effusion,pneumonia,respiratory failure,and pulmonary edema were the respiratory complications investigated. Results Thirty-four patients (69.4%) developed at least one respiratory complication during the early postoperative period.The most frequent complication was pleural effusion (n=26,53.1%),followed by pneumonia (n=8,16.3%),atelectasis (n=6,12.3%),acute respiratory failure (n=5,10.2%),pulmonary edema (n=2,4.1%).Compared to the patients who did not develop these problems,the affected cohort showed significantly higher mortality (P=0.048) ,had longer prothrombin time after operation (P=0.023),and was required more time to extubation(P=0.042).Only three patients who suffered pleural effusion required drainage. Conclusions Reducing the risk of early postoperative respiratory complications,early diagnosis and treatment of these problems are crucial for LT recipient survival.