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浓缩鱼油对实验性动脉粥样硬化的影响及机理探讨 被引量:22

INVESTIGATION ON THE EFFEC OF CONCENTRATED FISH OIL ON EXPERIMENTAL ATHEROSCLEROSIS AND ITS MECHANISM
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摘要 本文观察了浓缩鱼油(CFO)对实验性动脉粥样硬化(AS)形成、血浆及组织胆固醇含量变化、血浆高密度脂蛋白胆固醇(HDL一C)及其代谢酶活性、血小板分泌产物、血液流变学及培养的主动脉平滑肌细胞(SMC)增殖的影响。结果显示,CFO对实验性AS形成具有非常显著的抑制作用;CFO降低血浆总胆固醇(TC),同时阻止TC蓄积于动脉壁和肝脏,CFO升高血浆HDL一C,机制是刺激HDL合成酶及抑制其降解酶活性;CFO抑制血小板分泌血栓素A2(TXA2)、5一羟色胺(5一HT)及钙离子,促进其自身合成环磷酸腺替(cAMP);CFO通过降低血脂和纤维蛋白原水平使全血粘度降低;CFO对体外培养的主动脉SMC增殖具有显著的抑制作用。 he effect of concentrated fish oil(CFO)on experimental atherusclero-sis(AS),plasma and tissue cholesterol(TC),plasma,high density lipopro-tein cholesterol (HDL一C)and its metabolic enzyme activities,platelet meta-bolites,hemorheology and the proliferation of cultural aortic smooth musclcceils Were observed in rats and rabbits.The results showed that the areas of atherosclerotic plaque of aorta were significantly smaller.The total cho-lesterol(TC) levels from plasma and arterial wall were significantly lower but high density lipoprotein cholesterol(HDL一C)level was markedly elevated.Possi-bly the mechanism was:the activities of lecithin cholesteroI acyltransferase(LC-AT)and lipoprotein lipase(LPL)were increased and the activity of hepatic endo thelial lipase(HEL) was inhibited. CFO inhibited platelet aggregation as a consequence of decreasing TXA2/PGI2 ratio which might stimulate pla-elet cAMP synthesis and then decreased some agglutinating factors such as serotonin and calcium etc.releasing from platelet.On the other hand,CFO could inhibit the proliferation of the cultural aortic smooth muscle cells in rabbits.
出处 《营养学报》 CAS CSCD 北大核心 1994年第1期6-12,共7页 Acta Nutrimenta Sinica
基金 国家自然科学基金
关键词 浓缩鱼油 动脉粥样硬化 平滑肌细胞 fish oil concentrated atherosclerosis platelet metabolites high density lipoprotein cholesterol smooth muscle cell
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参考文献7

  • 1刘玉军,营养学报,1992年,14卷,17页
  • 2刘玉军,营养学报,1988年,10卷,119页
  • 3刘玉军,营养学报,1988年,10卷,341页
  • 4陈文杰,血液流变学,1987年
  • 5蒋宪成,上海第一医学院学报,1985年,12卷,151页
  • 6韩琴琴,上海第一医学院学报,1984年,11卷,181页
  • 7孙明堂,营养学报,1982年,4卷,45页

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