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咳嗽变异性哮喘与肺炎支原体感染的关系 被引量:21

Relationship between Cough Variant Asthma and Mycoplasma Pneumoniae Infections
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摘要 目的探讨咳嗽变异性哮喘(CVA)与肺炎支原体(MP)感染的关系。方法随机选择CVA患儿50例为观察组,50例同期就诊、年龄相仿的急性上呼吸道感染患儿为对照组。应用颗粒凝集法测定两组患儿MP IgM。结果观察组MP IgM阳性19例,阳性率38%;对照组阳性6例,阳性率为12%,两组比较有显著差异(χ2=9.013P<0.01)。观察组MP IgM滴度明显高于对照组,其中滴度≥1∶320者占47.4%(9/19例),而对照组较低,仅1例最高滴度为1∶320。19例CVA并MP感染的患儿在常规治疗基础上,加用阿齐霉素口服,总有效率84.2%(16例),随访6~24个月,无1例出现哮喘发作。结论CVA与MP感染关系密切,对CVA患儿应常规检测MP以排除MP感染,阳性者在按哮喘常规治疗同时予抗MP治疗,可取得满意效果。 Objective To explore the relationship between cough variant asthma (CVA) and mycoplasma pneumoniae (MP) infection.Methods Fifty children with CVA were chosen as the experimental group at random,and 50 children with acute upper respiratory infection,who went to the hospital in the same time and with similar age,were chosen as control group.The MP-IgM of children in both groups were tested by the granule agglutinating method.Results Significant difference (χ 2=9.013 P<0.01) was found between experimental group with 19 cases with MP-IgM positive,positive rate 38% and control group with 6 cases(12%).The MP-IgM titer distribution of experimental group[47.4%(9/19),more than or equal to 1∶ 320] was significant higher than that of control group(only one case equal to 1∶ 320).On a basis of conventional treatment,19 children with CVA complicated with MP infection took azithromycin orally.As a result,the effective cases were 16(84.2%) and they had no asthma outbreak after 6 to 24 months follow-up.Conclusions Close relationship is found between CVA and MP.The children with CAV shall check MP-IgM conventionally in order to exclude MP infection and the positive ones shall give anti-MP treatment on a base of asthma conventional treatment and satisfactory effectiveness can be expected.
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2005年第4期317-318,共2页 Journal of Applied Clinical Pediatrics
关键词 咳嗽变异性哮喘 肺炎支原体感染 儿童 cough variant asthma mycoplasma pneumoniae infection children
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