温胆汤治疗高血压病合并高脂血症146例临床观察

Clinical Observation on the Treatment of Combined Hypertension and Hyperlipemia with Wendan Decoction (WD,温胆汤),a Report of 146 Cases

目的:观察温胆汤治疗高血压病合并高脂血症的临床疗效。方法:将符合选择标准的该病患者2 78例随机分为两组。治疗组14 6例予温胆汤加味,对照组132例用开富特和非诺贝特,两组均治疗12周观察疗效。结果:治疗组显效72例,有效6 7例,无效7例,总有效率为95 .2 % (95 % CI=91.7%～98.7% ) ;对照组显效5 0例,有效4 2例,无效4 0例,总有效率为6 9.7% (95 % CI=6 1.9%～77.5 % ) ;两组综合疗效比较,有明显差异(u =3.4 35 1,P =0 .0 0 0 8) ;在降低舒张压及血脂方面,优于对照组(P <0 .0 0 1)。结论:温胆汤治疗高血压病合并高脂血症疗效优于开富特和非诺贝特,其收益为OR=0 .12 (95 %CI=0 .0 4～0 .34) ,NNT=4 (95 % CI=2 .91～5 .99)

Objective:To observe the effect of WD in treating c ombined hypertension and hyperlipemia.Method:278 patients were randomly divided into two groups.146 patients in the treatment group were treated with modified WD,132 patients in the control group were treated with captopil and fenofibr ate.Both the two groups were treated for 12 weeks.Result:In the treatment group, 72 cases significantly effective,67 cases effective,7 cases ineffective,the tota l effective rate was 95.2%(95%CI=91.7%～98.7%);While in the control group,50 cas es significantly effective, 42 cases effective,40 cases ineffective,the total ef fective rate was 69.7%(95%CI=61.9%～77.5%).The difference between the two groups in total effect was notable(u=3.4351,P=0.0008).The treatment group was supe rior to the control group in lowering diastolic pressure and blood lipid.Conclus ion:WD has better therapeutic effect than captopil and fenofibrate in treati ng combined hypertension and hyperlipemia.OR=0.12(95%CI=0.04～0.34),NNT=4(95%CI= 2.91～5.99).