罗格列酮对血糖正常的代谢综合征患者血管内皮功能和C反应蛋白的影响

Effects of rosiglitazong on endothelial function and C-reactive protein in nondiabetic patients with the metabolic syndrome

目的评价罗格列酮对血糖正常的代谢综合征患者血管内皮功能和C反应蛋白的影响。方法用随机双盲对照方法,选择血糖正常的代谢综合征患者190例,用高分辨率超声检测肱动脉血流介导的血管活性(FMD)和硝酸甘油介导的血管活性(NTGMD),计算胰岛素抵抗指数(IR)。结果罗格列酮+常规治疗组(试验组)较常规治疗组(对照组)FMD和NTGMD明显改善,IR变化2组具有显著性差异,血清hs-CRP水平显著下降(P<0.05)。结论罗格列酮能明显改善血糖正常的代谢综合征患者的血管内皮功能,并可减轻炎症反应。

Objective To assess the effects of rosiglitazong on vascular endothelial function and C-reactive protein(CRP) in non diabetic patients with the metabolic syndrome.Methods One hyndred ninety patients who met definition for the metabolic syndrome with normal serum glucose level were randomized to receive either rosiglitazong and conventional treatment (4mg, once a dayly, trial) or simple conventional treatment(control) for 8 weeks. Randomized,double-blind, controlled study was adopted. Flow mediated dilation (FMD) and nitroglycerine mediated dilation (NTGMD) were evaluated in the right brachial artery using high-resolution ultrasound machine.A serial serum biochemistry marker were detected and index of insulin resistance (IR) were calculated.Results Comparing with that of control group,the FMD and NTGMD of trial group were improved significantly (P<0.05),and serum high-sensitive CRP of trial group was decreased significantly (P<0.05).There was significantly different in the changment of IR between the two groups (P<0.05).Conclusion Rosiglitazong can significantly improve the endothelial function and alleviate the inflammatory reaction in the patients with normal glucose level and metabolic syndrome.