线粒体在细胞凋亡中的变化与作用

Mitochondrial Changes and Role in Apoptosis

在各种凋亡信号的诱导下,线粒体会发生显著的结构与功能性的变化,包括各种促凋亡蛋白(如细胞色素c,凋亡诱导因子等)的释放,线粒体膜电位的丢失,电子传递链的变化,以及细胞内氧化还原状态的变化;核转录因子以线粒体为中介也参与了细胞凋亡的调控。线粒体在哺乳动物细胞凋亡中具有核心地位和作用,昆虫细胞凋亡的研究表明,线粒体与昆虫细胞凋亡也有密切的关系。线粒体在细胞凋亡中的作用可能具有普遍意义。

Mitochondrion takes place in great changes in structure and function including the release of proapoptotic factors (such as cytochrome c, apopotosis inducing factor), loss of mitochondrial transmembrane potential, changes in electron transport, altered cellular oxidation-reduction etc, when cells are induced to undergo apoptosis by apoptotic stimuli. Transcriptional factors involve in the regulation of apoptosis through locating in mitochondrion. Mitochondrion play a role in central function on mammalian cell apoptosis. Recent studies revealed that mitochondrion has close relation with insect cell apoptosis. Mitochondrial function on apoptosis may be of universal significance.