格拉司琼联合地塞米松预防子宫切除术中不适反应20例

Effect of Granisetron Hydrochloride with Dexamethasone on Uncomfortable Reactions during Hysterectomy

目的观察格拉司琼联合地塞米松预防子宫切除术中不适反应的疗效。方法ASAIII级需行经腹子宫切除术的患者40例,随机双盲分为对照组和治疗组各20例。治疗组手术开始前静脉滴注格拉司琼溶液50mL(含格拉司琼3mg),10min内输完,滴注结束前即刻静脉注射地塞米松10mg。对照组手术开始前静脉注射0.9%氯化钠注射液50mL。观察两组患者手术前后血流动力学变化及寒战、恶心、呕吐及胸闷等不适反应情况。结果与手术开始前比较,两组患者术中血流动力学变化差异无显著性,治疗组恶心、呕吐发生率显著低于对照组(P<0.01)。寒战、胸闷等不适反应发生率亦低于对照组(P<0.05)。结论格拉司琼联合地塞米松能有效预防子宫切除术中寒战、恶心、呕吐及胸闷等不适反应的发生。

Objective To observe the effect of granisetron hydrochloride with dexamethasone on uncomfortable reactions during hysterectomy. Method Forty ASA Ⅰ-Ⅱ women undergoing hysterectomy were randomised into treatment group (n=20) and control group (n=20). A dose of granisetron hydrochloride 50 mL combined dexamethasone 10 mg was administered i.v. to each patient in the treatment group, while 0.9% sodium chloride injection 50 mL was given IV. to each patient in control group. The hemadynamic changes in both groups before and after the treatment were noted. Shiver, nausea, vomit and cardiac distress were recorded. Results There was no statistical difference in the hemadynamic change between the both groups. The occurrences of shiver, nausea, vomit and cardiac distress were significantly lowered in the treatment group than in the control group (P<0.05 or P< 0.01). Conclusion Granisetron hydrochloride combined dexamethasone can effectively prevent uncomfortable reactions during hysterectomy.