减肥对单纯性肥胖女生胰岛素和瘦素的影响

Effect of experimental reducing fat on leptin resistance and insulin resistance in adolecent girl students with simple obesity

目的 探讨减肥对单纯性肥胖女学生胰岛素和瘦素抵抗的作用。方法 抽取单纯性肥胖女学生 12 0名 ,采用有氧运动、合理饮食、心理矫正等措施进行为期 10个月的试验 ,用放射免疫方法测定试验前后血瘦素、胰岛素的变化。结果 单纯性肥胖女学生胰岛素和瘦素水平明显高于正常同龄人 ,减肥后胰岛素和瘦素水平明显下降。结论 肥胖女学生体内存在胰岛素和瘦素抵抗作用 ,试验减肥能改善肥胖女学生内体胰岛素和瘦素抵抗 ,从而起到调节异常内分泌代谢的作用。

Objective To investigate the effect of experimental reducing fat on leptin resistance and insulin resistance in adolecent girl students with simple obesity.Methods Simple obesity students accepted the reducing weight therapy composed of the aerobicexercise,reasonable diet,behavior modification for ten month.Then the changes of blood leptin and insulin were examined pre-and post-treatment.Results The leptin and insulin level were significantly higher in obese subjects than that in normal subjects,and the leptin and insulin level were decreased obviously after experimental reducing fat.Conclusion There are leptin resistance and insulin resistance in adolecent girl students with simple obesity.The experimental reducing fat can decrease the leptin and insulin level,so it plays an important role in adjusting metabolism disorder.