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接触二甲基甲酰胺对男工生殖内分泌机能影响 被引量:3

Effects of N, N-dimethylformamide reproductive endocrine of male workers
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摘要 目的研究二甲基甲酰胺(DMF)对男工生殖内分泌机能影响。方法按照国家标准测定作业场所空气中DMF浓度,并用尿中甲基甲酰胺(NMF)浓度来衡量作业工人实际接触水平,用化学发光免疫测定法(CLIA)测定了100名男工血清中卵泡刺激素(FSH)、黄体生成素(LH)、泌乳素(PRL)、睾酮(T)浓度。结果高水平DMF接触作业工人血清中T浓度[(30.15±8.37)g/L]高于低水平接触组[(25.36±10.69)g/L]和对照组[(18.56±8.07)g/L],而FSH浓度[(6.53±4.06)×10-3单位/L]则低于低水平接触组[(10.03±3.47)×10-3单位/L]和对照组[(12.63±6.55)×10-3单位/L];血清T浓度、异常率与DMF接触水平有明显剂量反应关系;高、低水平接触组T/LH比值(3.72±2.06、3.41±2.55)明显低于对照组(7.75±10.16)。结论DMF能使男工FSH变化外,尚存在间质细胞功能及LH T轴异常,对男工具有一定的生殖毒性。 Objective To investigate the reproductive endocrine effects on male workers exposed to N, N-dimethylformamide (DMF). Methods Air samples were collected in different work sites and the internal exposure to DMF was determined by measuring the concentration of DMF metabolite N-methylformamide (NMF) in urine. Reproductive hormones (T, LH, FSH, PRL) in serum from 100 male workers were measured by chemiluminesent immunoassay(CLIA). Results Compared with low DMF exposure [(25.36±10.69) g/L]and the controls group[(18.56±8.07) g/L], the concentration of T in serum in high DMF exposure [(30.15±8.37) g/L] significantly increased. While the FSH levels [(6.53±4.06)×10^-3 IU/L] in high DMF exposure groups were lower than those in low DMF exposure group [(10.03±3.47)×10^-3 IU/L] and the control groups ~[(12.63±6.55)×10^-3 IU/L] . There were dose-response relationship between DMF air concentration and T level or the abnormal rate of T serum. On the other hand, compared with the controls(~7.75±10.16 ), a significant decrease of the ratio of T/LH in both the high(3.72±2.06) and the low (3.41±2.55) DMF exposure groups were decreased.Conclusion Besides altering FSH in serum of male workers, DMF can damage leydigs cells and exhibits adverse effects on the LH-T axis.
出处 《中国职业医学》 CAS 北大核心 2005年第2期10-12,共3页 China Occupational Medicine
关键词 二甲基甲酰胺 生殖 内分泌 男工 N,N-dimethylformamide Reproduction Endocrine Male workers
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  • 1钱亚玲,蒋世熙,陆龙根,卢秀静.气相色谱法测定尿中甲基甲酰胺[J].劳动医学,1997,14(1):49-50. 被引量:14
  • 2张波,黄美媛,王玉玲,席力强,孙瑶,蔡世雄,李卫.二甲基甲酰胺对男工生殖结局的影响[J].中华劳动卫生职业病杂志,1993,11(2):78-80. 被引量:6
  • 3Chang HY, Shih TS, Guo YL, et al. Sperm function in workers exposed to N, N-dimethylfonnamide in the synthetic leather industry[J]. Fertil Steril,2004, 81 (6) :1589 - 1594.
  • 4Hellwlng J , Merkle J, Klimiseh HJ,et al. Studies on the prenatal toxicity of N, N-dimethylformarnide in mice, rats and rabbits [ J ]. Food Chem Toxicol,1991,29(3) :193.
  • 5GB/T1611105.车间空气中二甲基甲酰胺的气相色谱测定方法[s].[S].,..
  • 6Steinberger E. Hormonal control of spennatogenesis in man [ M ].New York :Roven Press ,1980. 139.

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