慢性阻塞性肺疾病与肺癌危险性关系的探讨

A Study of the Relation between Chronic Obstructive Pulmonary Diseases and the Risk of Lung Cancer

目的:分析慢性阻塞性肺疾病(chronicobstructivepulmonarydiseases,COPD)与肺癌危险性的关系。方法:对西安地区1999年至2001年肺癌组248例及对照组263例进行对照分析。结果:有慢性支气管炎、肺气肿的COPD患者,肺癌发生的OR值明显升高,分别为2.25和2.33。当FEV1<70%时,肺癌的OR值为2.28。结论:有COPD病史的患者,肺癌发生的危险性明显增高。肺功能的损伤增加了肺癌发生的危险性。

Objective: To analyze the relationship between chronic obstructive pulmonary disease (COPD) and the risk of lung cancer. Methods: The analysis was based on the data of a case-control study conducted during the period from 1999 to 2001 in Xi'an, China, and was evaluated by the odds ratio (OR). Results: The patients with COPD had an increased risk of lung cancer, OR=2.25 for Bronchitis and OR=2.33 for Emphysema. When FEV1 was lower than 70%, the risk of lung cancer increased (OR=2.28). Conclusion: The risk of lung cancer increases in the patients with a history of COPD, and the impairment of lung function is suggested to increase the risk of lung cancer.