摘要
目的 探讨肿瘤坏死因子α(TNF -α)、白细胞介素- 1β(IL - 1β)、白细胞介素- 6 (IL - 6 )、白细胞介素- 10 (IL- 10 )在老年多脏器功能障碍综合征(MODS)患者中的病理生理作用及其临床意义。方法 采用放射免疫法检测80例老年MODS患者的血清TNF -α、IL - 1β、IL - 6、IL - 10的动态变化。结果 老年MODS组的血清TNF -α、IL - 1β、IL - 6、IL - 10浓度较正常对照组明显升高(P <0 . 0 1) ,TNF -α、IL - 1β、IL - 6升高的峰值较IL - 10早,死亡组血清IL - 10浓度较存活组明显升高(P <0 . 0 1)。结论 细胞因子TNF -α、IL - 1β、IL - 6、IL - 10的异常释放参与了老年MODS的病理生理过程,选择不同时机以纠正细胞因子的失衡可能是今后的救治方向。
Objective To investigate the clinical significance and potential mechanism of plasma tumor necrosis factor (TNF-α), interleukin-1β(IL-1β),interleukin-6(IL-6),interleukin-10(IL-10)in the pathogenesis of multiple organ dysfunction syndrome(MODS) in the elderly critical patients.Methods The dynamic plasma levels of TNF-α,IL-1β,IL-6,IL-10 were measured in 80 MODS patients by using radioimmunoassay method.Results Plasma TNF-α,IL-1β,IL-6,IL-10 levels were significantly higher in MODS and SIRS group than those in healthy controls( P <0.01),the peak plasma levels of TNF-α,IL-1β,IL-6 reached more quickly than that of IL-10,Plasma IL-10 levels were significantly higher in dead group than those in survivors( P <0.01).Conclusions The abnormal release of TNF-α,IL-1β,IL-6,IL-10 play an important role in the pathophysiology of MODS with elderly patients.To maintain the balance of cytokines may be a method of treatment in future.
出处
《中国急救医学》
CAS
CSCD
北大核心
2005年第5期318-319,共2页
Chinese Journal of Critical Care Medicine
基金
浙江省医药卫生科学研究基金资助项目 (No .2 0 0 0B0 19)