老年心绞痛患者银杏叶黄酮治疗前后的自由基变化

Changed of Free Radical Levels of Senile Angiana Pectoris Patients Treated with Ginkgo Leaf Flavonoids

以邻苯三酚自氧化抑制法和硫代巴比妥酸反应产物比色分析法检测经用“天保宁”(银杏叶制剂)治疗50例心绞痛患者前后红细胞超氧化物歧化酶(E—SOD)活性及血浆过氧化脂质(P—LPO)和红细胞过氧化脂质(E—LPO)含量的结果表明,与治疗前相比,治疗后的E-SOD平均活性显著升高(P<0.01),P—LPO和E—LPO平均含量均显著降低(P<0.01)。提示老年心绞痛患者体内的病理性氧自由基反应和脂质过氧化反应在治疗后明显减缓,银杏叶黄酮具有较强的抗氧自由基损伤和抗脂质过氧化损伤作用。

Erythrocyte superoxide dismutase (E-SOD) activity, plasma lipoperoxides (P-LPO) and erythrocyte lipoperoxides (E LPO) contents of 50 senile angina pectoris patients who were treated by ginkgo leaf flavonoid (TAPONIN). The results showed that E-SOD activity after treatment was significantly higher than before treatment (P<0.001), P-LPO and E-LPO contents were lowered than before treatment (P<0. 001) after treatment. It suggested that ginkgo leaf flavonoid has the effects of anti-oxygen free radicals injury and anti-lipoperoxi-dation injury.