血肌酐、尿素氮与高血压并发症关系调查

THE REL ATION BETWEEN BUN AND Cr CON-CENTRATION AND THE COMPLICATIONS OF HYPFRTENSION

对原发性高血压有血肌酐、尿素氮异常的病人作了１：１病例对照研究。结果表明，有此异常的高血压患者的心肌梗塞、心绞痛、充血性心力衰竭、脑卒中发生率比正常者高（Ｐ＜０．００１），总病死率为３５．２％，后者为１６．４％（Ｐ＜０．００５）。当血肌酐超过２．５ｍｇ／ｄｌ，总病死率为５０％或６０％。因此，高血压肾功能不全是预测心脑血管并发症的一项强有力指标。

n general,the increase of blood urea nitrogen(BUN)and creatinine(Cr)concentrations denoted renal dysfnc-tion.However,the correlation of BUN and Cr concentration with stroke and cardiovascular disease in hypertension was rarely studied.A case-control study was conducted to inves-tigate the relation between them in 91 hypertensive patients with abnormal BUN and Cr concentration. The results showed that the group with renal dysfunction had higher in- cidence of myocardial infarction,angina pectoris,congestive heart failure and stroke than the group with normal BUN and Cr concentration(P<0. 001).Total fatal rate in renal dysfunction group was 35%which was higher than that in control group(16.4%)(P<0. 005).On the other hand,whenCr concentration exceeded 2.5 mg/dl,the fatal rate was50-60%which was higher than that in patients with normal Cr and slightly abnomal BUN(P<0.05).Our find-ings showed that renal dysfunction is hypertension is an in-dependent risk factor of stroke and cardiovascular disease,and the fatal rate increased when Cr concentration exceeded 2.5mg/dl.