金纳米壳球体的制备及其潜在的生物学应用

Fabrication of Gold Nanoshells and Their Potential Applications to Biology

利用分子自组装和胶体还原化学制备出具有核-壳结构的金纳米壳球体Au@SiO2;通过透射电子显微镜(TEM)、X射线光电子能谱(XPS)和紫外-可见分光光度计对Au@SiO2的制备过程及其在全血中的光学特性进行了研究.结果表明,通过改变复合颗粒Au-APTES-SiO2的浓度,可以得到具有合理核-壳比例的Au@SiO2,其等离激元共振峰位于光谱的近红外区,这使得具有红外消光特性的金纳米壳球体具有潜在的生物学应用价值.

Molecular self-assembly and colloid reduction chemistry were used to fabricate gold nanoshells Au@SiO2 with core-shell structures. Transmission electron microscopy (TEM), X-ray photoelectron spectrometer (XPS) and UV-vis spectrophotometer were employed to investigate the fabrication process of Au@SiO2 and their optical properties in whole blood. Our results demonstrate that by varying the concentrations of composite particles Au-APTES-SiO2, the gold nanoshells with appropriate core-shell ratio could be obtained and the plasmon resonances of these nanopaticles could be located in the infrared region of the spectrum, suggesting that gold nanoshells with infrared extinction properties have potential biological applications.