山东地区农民人群糜烂性反流性食管炎的发病研究

A mass survey on the morbidity of erosive reflux esophagitis in farmers of Shandong province

目的研究山东农村地区自然人群中糜烂性反流性食管炎的发病情况。方法对山东烟台地区农村人群(年龄40-90岁)随机抽样587例,行内镜及活检组织快速尿素酶检查。结果共检出糜烂性反流性食管炎87例,患病率为14.8%(87/587)。①患病率按年龄分组:40-49岁组10.0%(2/20)、50-59岁组13.0%(38/293)、60-69岁组16.7%(31/186)、70岁以上组18.1%(16/88)。②糜烂性反流性食管炎按性别分组:男67例、女20例,男:女为3.35:1。③糜烂性反流性食管炎患者中Hp阳性检出率:52.9%(46/87)。这一人群的Hp阳性检出率:56.0%(329/587),两者Hp阳性检出率差别无统计学意义(P>0.05)。④糜烂性反流性食管炎患者按洛杉矶分类各级的比例:A级:54.0%(47/87)、B级:35.6%(31/87)、C级:9.2%(8/87)、D级:1.1%(1/87)。结论糜烂性反流性食管炎随着年龄的增加患病率和分级的严重程度均增加,男性患病率高于女性,与Hp感染无相关性。

Objective To investigate the incidence of erosive reflux esophagitis in farmers of Shan-dong province. Methods Five hundred and eighty seven peasants (aged from 40 to 90 years old) were ran-domly selected from the rural general population in Yantai area, Shandong Province. Endoscopy and CLO test were performed in all subjects. Results Among them 87 patients were confirmed to have erosive reflux esophagitis, the morbidity rate is 14.8% (87/587). The morbidities in each age groups were 40-49 age group 10. 0% (2/20) , 50-59 age group 13.0% (38/293) , 60-69 age group 17% (31/186) and over 70 years old groups; 18% ( 16/88) ; males 67 cases, females 20 cases, male and female ratio 3. 35:1. H. pylo-ri positive rate in erosive reflux esophagitis was 52. 9% (46/87). H. pylori positive rate in the population was 56. 0% (329/587) , there was no significant difference between H. pylori positive rate of the two groups( P > 0. 05). According to Los Angeles classification system the types distributed as A; 54. 0% (47/87 ) , B: 35. 6% (31/87) , C: 9. 2% (8/87 ) and D: 1. 1 % ( 1/87 ). Conclusion The morbidity of erosive reflux esophagitis rate is increasing parallel with the increase of age and severity of the lesion, and prevalence is more in males than females. The morbidity rate in males was higher than that in females. The incidence of e-rosive reflux esophagitis is not affected by H. pylori infection.