放射性舌下神经损伤的影响因素

Risk Factors of Radiation-Induced Hypoglossal Nerve Palsy

目的 探讨鼻咽癌患者放射治疗后发生舌下神经损伤的影响因素。 方法 随访观察32 6例接受根治性放射治疗的鼻咽癌患者,将可能影响放射性舌下神经损伤的相关因素通过Logistic回归模型进行分析。 结果 放射性舌下神经损伤的发生率为10 .4 % (34/ 32 6 ) ,潜伏期为10～84个月(中位潜伏期39个月)。选入回归方程的因素有N分期、上颈部照射剂量与发生颈部皮肤急性放射毒性。 结论 颈淋巴结N分期、上颈部照射剂量与发生上颈部皮肤急性放射毒性、放射性舌下神经损伤有关。

Objective To study the affective factors of radiation-induced hypoglossal nerve palsy in patients with nasopharyngeal carcinoma. Methods Respectively observed 326 patients with nasopharyngeal carcinoma who received radical radiotherapy. To analyze the affective factors that might cause the radiation-induced hypoglossal nerve palsy by using Logistic regression model. Results The occurrence of radiation-induced hypoglossal nerve palsy was 10.4%(34/326), and the latency period was 10～84 months(median 39 months). The chosen factors in the regression formula were N staging, total dose of external radiation for superior neck and acute radiation-related dermatitis of superior neck. Conclusion N staging, total dose of external radiation for superior neck and acute radiation-related dermatitis of superior neck were relevant with radiation-induced hypoglossal nerve palsy in patients with nasopharyngeal carcinoma.