p53 CD44V6及nm23/NDPK在非小细胞肺癌中表达的相关性分析

Relationship between Expression of p53, CD44V6 and nm23/NDPK in Non-small Cell Lung Cancer

目的:探讨非小细胞肺癌(NSCLC)中p53、CD44V6及nm23/NDPK表达的相关性及预后意义。方法:采用免疫组织化学SP法对69例NSCLC组织中p53、CD44V6及nm23/NDPK进行检测。结果:p53、CD44V6及nm23/NDPK的表达与NSCLC患者的临床分期(P<0.05,P<0.01)、淋巴结转移(P<0.05,P<0.01)及生存率(P<0.05)密切相关。p53、CD44V6表达与nm23/NDPK在NSCLC中的表达呈明显负相关(P<0.01)。结论:联合检测NSCLC中p53、CD44V6及nm23/NDPK的表达对于判断预后和指导治疗可能具有实用价值。

Objective: This study was designed to investigate the expression of p53,nm23/NDPK and CD44V6 and their correlations in non-small cell lung cancer (NSCLC). Methods: The expression of p53, CD44V6 and nm23/NDPK was immunohistchemically detected using SP methods in 69 cases with NSCLC. Results: The expression of p53, CD44V6 and nm23/NDPK was significantly related with the staging of the disease (P<0.05, P<0.01), the lymph node involvement ratio (P<0.05, P<0.01) and postoperative survival (P<0.05). Conclusion: Combined detection on the expression of p53, CD44V6 and nm23/NDPK in NSCLC may has the practical value in prognosis of the patients.