基质金属蛋白酶-3在脑动脉瘤和脑外伤患者血清中的含量及意义

Detection of Serum MMP-3 in Patients with Cerebral Aneurysm and Cerebral Trauma

目的 观察脑动脉瘤患者血清基质金属蛋白酶-3(MMP-3)的含量变化,探讨其在脑动脉瘤发生发展过程中的作用和意义。方法 用ELISA法检测脑动脉瘤患者36 例,脑外伤患者37 例,正常对照组32 人血清MMP- 3 的含量。结果 脑动脉瘤患者血清中MMP- 3 含量为(92. 7±6.7)ng/ml,显著高于正常人(33. 6±3. 7 ng/ml, P < 0. 001) 、脑外伤患者(52. 1±4. 9 ng/ml, P <0.01)。结论 MMP-3在脑动脉瘤发展过程中起着重要的作用。

Objective To investigate the role and clinical significance of serum MMP-3 in cerebral aneurysms. Methods Serum levels of MMP-3 were detected in 36 controls with cerebral aneurysms, 37 with cerebral trauma, and 32 normal persons by ELISA method. Results The levels of MMP- 3 in the serum of cerebral aneurysms patients were (92.7±6.7)ng/ml. Which is higher than those of controls (33.6±3.7ng/ml, P<0.001) and cerebral trauma patients (52.1±4.9ng/ml, P< 0.01). Conclusions MMP-3 may contribute the pathologic course in the pathological stage of cerebral aneurysms.