癫痫发作及电针时大鼠脑内c-fos蛋白的表达

C-fos expression in rat brain during seizure and electroacupuncture

本实验在海马青霉素致痫模型上观察了致痫及致痫加电针后脑内c-fos蛋白的变化,结果表明致痫时海马CA_1区、齿状回、梨状皮层、背测内嗅皮层、杏仁核见到较多的c-fos表达,电针后c-fos在CA_1区明显减少,在CA_3区及上述余各区则显著增加,提示:致痫能引起与癫痫发作有关的某些核团c-fos表达,电针抗痫作用可能和调节上述部位c-fos表达有关。

C-fos proteins were visualized immuno-histochemically in the brain of rats after seizures induced by injecting penicillin into hippocampus and by penicillin + electroacupuncture treatment. Three hours following seizures there was an evident expression of c-fos proteins in the hippocampus (CA1 area), dentate gyrus, piriform cortex, dorsal part of entorhi-nal cortex, and amygdaloid nucleus, and there was a dramatic increase of c-fos proteins in CA3 area and the areas mentioned above except the CA1 area where c-fos proteins apparently decreased after electroacupuncture treatment. The results showed that seizures can induce c-fos proteins in some nuclei related with seizure and that electroacupuncture can also regulates the c-fos expression after seizure.