我国真菌性角膜炎的研究现状

Progress of diagnosis and treatment of fungal keratitis in China:current status

真菌性角膜炎发病率逐年增高,致盲率居高不下,临床治疗棘手。早期诊断、及时治疗可明显改善预后。近年来,随着对真菌性角膜炎认识的提高,早期正确诊断率有较大提高;利用分子生物学技术对真菌性角膜炎的快速诊断研究及分型诊断也取得了进展;组织病理学研究提示真菌的菌株不同、对角膜的感染方式以及在组织内的生长方式可能不相同;手术方式的探索也较大程度地改善了预后。为了更有效地治疗真菌性角膜炎,许多基础和临床工作还有待完成。

Fungal keratitis is a knotty eye disease with high rate of blindness.Early diagnosis and treatment can remarkably improve its prognosis.In recent years,the more knowledge of fungal cornea infection is achieved,and correct diagnosis rate is raised greatly.Quick diagnosis and typing of fungal keratitis with molecular biology also have been developed.Using histopathology techniques,it has been testified that different fungal strains have different infective ways in corneal tissues,and probably different growing modes in tissues.With exploring surgery methods,prognosis of fungal keratitis has been improved.In order to effectively treat fungal keratitis,a lot of basic and clinical researches should be done.