大承气汤对实验性肺损害促修复作用的观察

Observation on the Restoration-Promoting Effect of Major Chengqi Decoction on Experimental Pulmonary Damage

本文介绍了人工致直肠狭窄导致大肠燥屎蕴结,肺气上逆后模型鼠所出现的反应性肺脏损害,尤其是电镜下的超微结构改变。指出肺充血、水肿、出血以及肺泡壁Ⅰ、Ⅱ型上皮细胞的肿胀变性和某些功能的改变等是构成肺失肃降的病理之一。大承气汤对上述肺损害有明显促修复作用,其机理可能与肠源性内毒素等因素有关。文章同时指出,对“肺与大肠相表里”学说的深入研究不仅可为临床“通腑护脏疗法”提供坚实的理论基础,而且必将能开拓出“通腑护脏疗法”辨治的新领域。

This paper introduces the reactive pulmonary damage, especially the ultrastructural changes under electron microscope of model rats with coproma in the large intestine and rebellion of lung qi caused by artificial rectum stricture. It is pointed out that the pulmonary congestion, edema and hemorrhage, swelling degeneration of Ⅰ and Ⅱ types of pulmonary epithelia cells ,and some functional changes are the pathological bases for resulting in failure of lung in depurative descending. The Major Chengqi Decoction has obvious restoration-promoting effect on the above-mentioned damages and its mechanism may be related to the entergenous endotoxin. It is also proposed that the deeper studies on the doctrine of 'the lung and large intestine are interior-exterior related' world provide a solid theoretical basis for the clinical therapy of 'dredging the fu-viscera to protect zang-viscera' as well as exploit a new field for the application of the therapy of 'dredging the fu-viscera to protect zang-viscera'.