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质子泵抑制剂无效非糜烂性反流病夜间烧心症状的治疗

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摘要 目的探索非糜烂性反流病(NERD)夜间烧心症状的人性化用药方案。方法54例经质子泵抑制剂治疗仍发生夜间烧心症状的NERD患者随机分为三组,每组18例,在每日口服2次奥美拉唑每次20mg的基础上,分别于夜间睡前加服奥美拉唑20mg、法莫替丁40mg和法莫替丁40mg加阿普唑仑0.4mg,疗程1周。比较治疗后各组夜间烧心症状的程度、夜间pH<4的时间百分比和夜间酸突破(NAB)的发生率。结果奥美拉唑组夜间pH<4的时间百分比和NAB发生率均较高(P<0.001和P<0.05),法莫替丁组和联用阿普唑仑组间差异则无统计学意义(P>0.05和P>0.05);法莫替丁组平均夜间烧心症状的VAS总积分低于奥美拉唑组(P<0.05),但高于联用阿普唑仑组(P<0.05)。结论阿普唑仑能帮助法莫替丁减少NERD夜间烧心症状。
出处 《医师进修杂志》 2005年第6期25-27,共3页 Journal of Postgraduates of Medicine
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