摘要
桂枝汤能抑制蛙皮素对冷环境中大鼠的降温效应,并不影响等效价蛙皮素及其受体拮抗剂D-苯丙12-蛙皮素合并脑室注射引起的体温改变,亦能翻转D-苯丙12-蛙皮素在发热大鼠上的升温作用,提示桂枝汤对体温的双向调节,部分通过对下丘脑体温调节中枢中蛙皮素受体的调节起作用。
Hypothennia induced by adininistration of bombesin into the lateral ventricle of brain in cold exposed rats could be inhibited by Guizhi Tang (GZT).The GZT could also reverse the potency of fever induced by injection of [D-Phe12] bombesin,a bombesin receptor antagonist,into the brain of febrile rats.But there was no effect of GZT on body temperature when bombesin and[D-Phe12] bombesin were simultaneously injected into the lateral ventricle of cold exposed rats.These studies indicated that the dual-directional thermoregulation of GZT was carried out partially by affecting the bombesin receptor in thermoregulation center of hypothalamus.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1994年第2期99-100,共2页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家中医药管理局重点课题资助
关键词
桂枝汤
体温调节
蛙皮素
Guizhi Tang,dual-directional thermoregulation,bombesin,[D-Phe^(12)] bombesin