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近视研究中动物模型的选择 被引量:17

Selection of animal model in myopia research
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摘要 近视动物模型是近视研究的重要工具,但在动物选择、处理方法等问题上存在很多差异和争议。近视动物模型的选择不仅可决定实验研究成功与否,还能决定实验结果是否准确和正确。因此,有必要围绕近视动物模型中几个有争议的问题展开讨论,同时提出一些意见,仅供参考。 Animal model plays an important role in myopia research. However discrepancy and deputed have been existed in animal model making, including animal selection, myopia inducing methods. The model selection can not only determine the success of experiments but also impact the accuracy of study outcome. Here are summaries and comments round disputed issues which are hoped to be useful for animal myopia researches.
作者 周翔天 瞿佳
出处 《中华眼科杂志》 CAS CSCD 北大核心 2005年第6期486-487,共2页 Chinese Journal of Ophthalmology
关键词 动物模型 近视 动物选择 处理方法 实验研究 Myopia Models, animal
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参考文献6

  • 1Wallman J, Turkel J, Trachtman J. Extreme myopia produced by modest change in early visual experience. Science, 1978, 201: 1249-1251.
  • 2胡诞宁.近视的病因与发病机制研究进展[J].眼视光学杂志,2004,6(1):1-5. 被引量:108
  • 3Siegwart JT, Norton TT. The time course of changes in mRNA levels in tree shrew sclera during induced myopia and recovery. Invest Ophthalmol Vis Sci, 2002, 43:2067-2075.
  • 4Gentle A, Liu Y, Martin JE, et al. Collagen gene expression and the altered accumulation of scleral collagen during the development of high myopia. J Biol Chem, 2003,26:26-30.
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