脾虚证患者胃运动功能的研究

Studies on Gastric Motility of Patients with Spleen-Deficiency Symptoms

采用同步检测胃平滑肌电活动和腔内压力变化的方法及血浆胃动素放射免疫测定法，对６３例各型脾虚证患者的胃运动功能进行研究。结果显示：各型脾虚证患者胃电节律紊乱的程度和电—机械脱偶联率均显著高于健康人；腔内压力波的各项指标均较健康人降低；血浆胃动素水平呈增高趋势，并与胃电节律紊乱成正相关。提示各型脾虚证患者胃运动功能异常的可能机制是血浆胃动素水平增高→胃电节律紊乱→胃机械运动功能障碍。这种同步检测胃运动功能的方法有助于揭示胃电活动与机械运动间的内在联系。

By using a method for synchronously-detecting gastric myoelectric activity and intraluminal pressure and a radioimmunoassay of plasmic motilin, gastric motility, plasmic level of motilin and their relationship in 12 normal individuals and in the patients with a variety of Spleen-Deficiency (SD) Syndromes, i.e. 12 SD with Cold type (H type), 7 SD with Stomach-Yin-Deficienctype(I type), 38 SD with Heat type (R type) and 6 SD with Liver-Qi-Stagnation type (U Type) were investigated. The results showed: degree of myoelectric dysrhythmia and rate of electro-mechanical decouple in all patients (except for I type) were much higher than those in the normals (P<0.01 or P<0.05), both mean frequency and amplitude of contraction in the patients were decreased: percentage of contractive action in the patients (except for I type) was lower than that in the normals (P<0.05);plasmic level of motilin in the patients (except for I type) had a tendency to increase and had a linear correlation to degree of myoelectric dysrhythmia (r=0.33, P<0.01). It was suggested that some significant disorders of gastric motility exist in different SD patients and there might be an intrinsic cause effect relationship among increased plasmic motilin, myoelectric dysrhythmia and abnormal mechanical motion. The similar changes suggested that there is pathophysiological mechanism of SD sydrome. Furthermore, this synchronously-detecting method was useful to discover intrinsic relationship between gastric myoelectric activity and mechanical motion.