摘要
目的探讨不同剂量氨茶碱和肾上腺素在大鼠窒息致心脏停搏模型中的疗效。方法呼气末夹闭气管8min,建立大鼠心脏停搏模型。48只大鼠随机分为氨茶碱和肾上腺素组,比较两组大鼠不同剂量的复苏疗效。结果心电活动恢复率氨茶碱组与肾上腺素组相比,差异无显著性(P>0.05);两组自主循环差异无显著性(P>0.05)。氨茶碱和肾上腺素复苏疗效均与剂量呈正相关。肾上腺素组心脏硬度记分显著高于氨茶碱组,且剂量越大,心脏硬度记分越高。结论在窒息致心脏停搏大鼠模型中,氨茶碱对心电活动和自主循环的恢复与肾上腺素疗效相近;氨茶碱和肾上腺素的复苏疗效与剂量相关;较高剂量肾上腺素容易致“石头心”的发生。
Objective To compare the efficacy of different doses of aminophylline and epinephrine on cardiac arrest in rats.Methods Asphyxial cardiac arrest was induced by clamping the endotracheal tube.After 8 minutes of cardiac arrest,48 rats received either intravenous aminophylline or epinephrine in a randomized manner.Results The rate of cardiac electrical activity restoration and spontaneous circulation recovery weren't significantly different between the two groups.Results The more aminophylline or epinephrine was repeatedly given(3×10 mg/kg as highest dose),the more rats had a return of cardiac electrical activity and spontaneous circulation.At autopsy the cardiac consistency score in epinephrine group was significantly higher than that in aminophylline groups.Conclusion Aminophylline could improve cardiac electrical activity and spontaneous circulation in rats with cardiac arrest.The dose of aminophylline and epinephrine is positively correlated with the efficacy of resuscitation.The incidence of'stone'heart is high if high-dose epinephrine administration.
出处
《中华急诊医学杂志》
CAS
CSCD
2005年第6期482-484,共3页
Chinese Journal of Emergency Medicine