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慢性丙型肝炎病理学研究 被引量:14

THE PATHOLOGY OF CHRONIC HEPATITIS C
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摘要 观察了68例慢性丙型肝炎例(47慢性迁延性肝炎,21例慢性活动性肝炎)及32例慢性乙型肝炎的肝穿刺活检标本。68例丙型肝炎中50例显示不同程度的肝细胞脂肪变;47例显示汇管区显著的淋巴细胞聚集,有时形成淋巴滤泡;肝窦中炎细胞浸润明显,但小叶内肝细胞变性、坏死较轻,本研究还提示丙型肝炎时肝细胞的损伤可能主要与丙型肝炎病毒的直接作用有关。 68 liver biopsy specimens from patients with chronic hepatitis C(47 cases withCPH and 2l cases with mild or moderate CAH)and 32 specimens from paticnts withchronic hepatitis B(17 cases with CPH and l5 cases with CAH)were studied to de-termine the histopathological features of hepatitis C。 The cases with hepatitis C wereconfirmed by serological tests including test for anti-HCV antibody。 Hepatocytic stea-tosis in various degree was detected in most of the cases(50/68)of hepatitis C; denselymphoid aggreg ates in portal tracts were found in 47 cases,Sometimes forming lymp-hoid follicles ; much pronounced sinusoidal infiltrates of lylnphocytes and Kupffer cellhyperplasia appeared in hepatitis C cases in;pite of milder acidophilic degenerationand focal necrosis of hepatocytes in the acini as compared with cases of hepatitis B。The histopathological features of chronic hepatitis C were discussed and it is suggestedthat in hepatitis C the hepatocellular damage might result to a great extent from thedirect cytopathic ef fect of the HCV。
出处 《中华传染病杂志》 CAS CSCD 北大核心 1994年第4期196-198,共3页 Chinese Journal of Infectious Diseases
关键词 丙型肝炎 组织病理学 病理学 Chronic hepatitis Hepatitis C Histopathology
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