纳米羟基磷灰石人工骨的生物相容性研究

Biocompatibility study of nano-hydroxyapatite artificial bone

目的评价新型纳米羟基磷灰石人工骨的生物相容性,从而为其在骨缺损修复领域中的临床运用提供依据。方法分别进行急性毒性试验、热原试验、皮内试验、肌肉植入试验、骨植入试验等生物相容性试验。结果这种纳米羟基磷灰石人工骨材料无毒,无热原性,植入兔肌肉后逐渐发生降解。结论此纳米羟基磷灰石人工骨材料具有良好的生物相容性。

[Objective] To study the biocompatibility and safety of nano-hydro xyapatite artificial bone for the clinical use in the bone's reconstruction fiel d. [Method] Evaluated the biocompatibility through the experiments including a cute systemic toxicity test,pyrogen,intracutaneous test and long-term muscle and bone implant test. [Results] All results indicated that the material had no t oxicity,no irritation to skin and did not contain the pyrogen material. [Conclu sion] The nano- hydroxyapatite (nano-HA) artificial bone possesses excellent bi ocompatibility.