己酮可可碱防治犬呼吸窘迫综合征的研究

Effects of pentoxiylline on respiratory distresssyndrome in dogs.

应用己酮可可碱（ＰＴＸ）对犬脂肪型呼吸窘迫综合征进行早期治疗，发现治疗后ＰａＯ＿２下降减慢，支气管肺泡灌洗液（ＢＡＬＦ）中白细胞总数显著下降，肺泡巨噬细胞分泌白介索１与肿瘤坏死因子减少，ＢＡＬＦ中白蛋白含量及肺湿／干比值明显降低，肺病理损害减轻。表明ＰＴＸ可显著减少肺内白细胞蓄积，减轻肺血管渗出和肺水肿形成，其机理可能与ＰＴＸ抑制炎症细胞、保护肺血管内皮等有关。

e examined effects of early post-treatment withpentoxifylline(PTX) on fat tissue extract(FTE)in-dueed respiratory distress syndrome in dogs.The re-sults indicate that the arterial ox ygen tension in theanimals reeeived PTX dropped more slowly,the totalleukocytes and albumin in BALF were obviously re-duced,the increased production of IL-1 and TNF byalveolar macrophages was partly inhibited, otherparameters such as W / D ratio were also markedlydecreased when compared to the animals reeeivedFTE only.PTX decreases neutrophil accumulationand prevents the increase in pulmonary vascularpermeability, and attenuates edema formation inFTE-induced lung injury.The mechanism may relatewith the effect of PTX inhibiting inflammatoryleukocytes and protecting the pulmonary vascuiarendothelial cells.