摘要
目的:探讨醒酒保肝胶囊的解酒、防醉以及对酒精性肝损伤的影响。方法:昆明种SPF级雄性小白鼠156只,建立急性酒精中毒动物模型,分别进行防醉、解酒,对急性酒精性肝损伤保护作用试验进行观察。结果:醒酒保肝胶囊可明显减少醉酒动物数目(P<0.05),缩短醉酒动物的睡眠时间(P<0.05),而且可以抑制乙醇引起的小鼠肝组织中丙二醛(MDA)含量升高(P<0.05),提高肝组织中还原型谷胱甘肽(GSH)含量(P<0.05),抑制由乙醇引起的血清甘油三酯(TG)含量的升高(P<0.05)。结论:醒酒保肝胶囊具有防醉、解酒作用,且对乙醇引起的急性肝损伤具有一定的保护作用。
Objectives: To establish acute alcoholism model with alcohol (50%) and explore the effectiveness of Xingjiubaogan capsule on prevention and treatment of alcoholic liver disease. Methods:156 male mice(SPF) were randomized into groups, et al. We have anti-temulence、alleviating a hangover and explore the effectiveness of Xingjiubaogan capsule experiment respectively. All the mice were fed normal diet. Results: The acute alcoholism model was made. The number of drunkenness mice and the time of amethyst have significant difference in the Xingjiubaogan capsule groups VS model group(P<0.05). The activity of MDA and content of TG were increased comparing with Xingjiubaogan capsule groups(P<0.05). Conclusions: The Xingjiubaogan capsule has the clear effectiveness of anti-temulence and alleviating a hangover, therefore, it has the definite protective action to acute alcoholic liver disease in the mice .
出处
《新疆医科大学学报》
CAS
2005年第5期396-398,共3页
Journal of Xinjiang Medical University
关键词
醒酒保肝胶囊
酒精性肝损伤
防醉作用
解酒作用
抗氧化
Xinjiubaogan capsules
alcoholic liver disease
anti-temulence
alleviating a hangover
antioxidation