下肢静脉性溃疡与白细胞浸润和新生血管的关系

The relationship between white blood cell infiltration and neovascularization in venous ulceration of lower limbs

目的探讨白细胞浸润和新生血管与下肢静脉性溃疡的关系。方法采用不同体位下肢血常规白细胞计数和免疫组织化学法测定微血管密度,比较溃疡组、无溃疡组和对照组的白细胞计数和微血管密度。结果溃疡组中,患肢下垂位血白细胞计数比平卧位减少23.7%,与其他组相比差异有统计学意义(P<0.05);患肢皮肤中白细胞和微血管密度比其他组明显升高,差异有统计学意义(P<0.01);白细胞与微血管密度呈显著正相关(r=0.73,P<0.05)。结论白细胞浸润和新血管生成是下肢静脉性溃疡发生发展的重要因素。

Objective To investigate the relationship of venous ulceration to white blood cells (WBC) and microvessel density (MVD).Methods The cases were divided into ulceration group,non- ulceration group and control group.WBC and MVD were analyzed by blood routine and immunohistochemistry in different positions.Results In ulceration group,the blood WBC of patients sitting with leg dependent were decreased by 23.7% as compared with those of lying supine,showing a significant difference in contrast to the other two groups (P< 0.05).WBC and MVD of skin were increased obviously in ulceration group as compared with the other two groups (P< 0.05).WBC was positively correlated with MVD (r= 0.73, P< 0.05).Conclusion WBC infiltration and neovascularization are important factors in the process of occurrence and development of venous ulceration.