注射用β-七叶皂苷钠不良反应分析

Analysis of Adverse Drug Reactions of Sodium Aescinate

目的:了解注射用β-七叶皂苷钠所致药品不良反应的规律和特点,为减少和避免ADR的发生提供参考。方法:通过检索中国期刊网CNKI数字图书馆上的中国期刊全文数据库,对1994～2004年国内期刊上公开报道的31例注射用β-七叶皂苷钠引起的药品不良反应进行统计分析。结果:该药品不良反应多见于男性中、青年患者,以皮肤及附件损害为主;该药所致的肾功能损害应引起我们的高度重视;45.16%的ADR出现时间在1d内。结论:β-七叶皂苷钠所导致的不良反应一般比较轻微,治疗预后良好,但临床使用中注意观察患者反应情况,及时发现,及时治疗,以避免严重ADR的出现。

Objective:To reduce and avoid ADRs of Sodium Aescinate by analyzing the feature of the drug's ADRs.Methods:Statistically analyzing the ADRs of Sodium Aescinate of 31 cases reported publicly between 1994 and 2004 by searching in the database of the website of CNKI. Results:The ADRs of Sodium Aescinate are found more occurring on young males, the damage of skin is the main kind one with that of renal fuction which should be paid more attention to. And 45.16% of the ADRs occured within 1 day.Conclusion:In general, the ADRs of Sodium Aescinate are slight and can be cured,but the conditions of the patients should be observed carefully to avoid the occurring of severe ADRs.