摘要
目的观察不同雾化吸入方法对慢性阻塞性肺疾病(COPD)患者肺功能及血气的影响。方法将40例COPD患者随机分为观察组和对照组,各20例,用相同剂量异丙托溴铵,观察组用压缩雾化吸入法,对照组用超声雾化吸入法。比较两组治疗前、后第1秒钟用力呼气容积(FEV1)、最大呼气峰流速(PEF)及PaO2、PaCO2的变化。结果两组治疗前FEV1、PEF与治疗后比较,差异有显著意义(P<0.01,P<0.05);观察组PaO2、PaCO2治疗前、后差异有显著意义(均P<0.05);治疗后观察组各观察指标较对照组显著改善(均P<0.05)。结论压缩雾化吸入法能降低COPD患者的呼吸道阻力,改善肺功能,其治疗效果优于超声雾化吸入法。
Objective To evaluate the equivalence of compression atomized and ultrasonic atomized inhalation for patients with chronic obstructive pulmonary disease (COPD). Methods Forty patients with COPD were randomly divided into two groups: treatment group (20 cases) and control group (20 cases). The patients in treatment group inhaled Ipratropium Bromide Solution by compression atomized inhalation and those in control group inhaled Ipratropium Bromide Solution by ultrasonic atomized inhalation. Lung function markers including FEV_1 and PEF and arterial blood gas were measured. Results Both groups had significant increases in FEV_1 and PEF ( P<0.01 in treatment group, P<0.05 in control group). PaO_2 and PaCO_2 in treatment group had significant changes (all P<0.05). There were significant differences in FEV_1, PEF, PaO_2 and PaCO_2 between two groups (all P<0.05). Conclusion The effect of compression atomized inhalation in improving lung function and decreasing resistance of airway is better than that of ultrasonic atomized inhalation.
关键词
慢性阻塞性肺疾病
压缩雾化吸入
超声雾化吸入
chronic obstructive pulmonary disease
compression atomized inhalation
ultrasonic atomized inhalation