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S-100B蛋白在颅脑损伤诊断及预后评价中的临床意义 被引量：7

Clinical significance of serum S-100B protein in diagnosis and prognostic of head injury
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摘要 通过测定 12 0例颅脑损伤患者血清S 10 0B蛋白浓度 ,明确其在颅脑损伤诊断及预后评价中的意义。认为血清S 10 0B蛋白浓度是判断颅脑损伤程度和预后评价较为理想的生物学指标。
作者 胡殿雷 柳宪华 于效良 郭红梅 郭兵 石岩 庄会林 施鹏
机构地区 徐州市第三人民医院神经外科 徐州市第三人民医院检验科 徐州市第三人民医院CT室
出处 《创伤外科杂志》 2005年第2期133-133,共1页 Journal of Traumatic Surgery
关键词 S-100B蛋白 颅脑损伤 预后
分类号 R651.1 [医药卫生—外科学]
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  • 1Raabe A, Seifert V. Fatal secondary increase in serum S - 100B protein after severe head injury. J Neurosurg, 1999, 91 (5):875 -877.
  • 2Raale A, Grolms C, Keller M, et al. Correlation of computered tomography finding and serum brain damage markers following severe head injury. Acta Neurochir, 1998, 140(8): 787 - 791.
  • 3Ingebrigtsen T, Romner B. Kongstad P, et al. Increased serum concentrations of pritein S-100 after minor head injury: A biochemical serum marker with prognostic value? (letter) J Neurol Neurosurg Psychiatry, 1995,59(1): 103 - 104.
  • 4Romner B, Ingebrigtsen T, Kongstad P, et al. Traumatic brain damage: serum S-100B measurements related to neuroradiological findings. J Neurotrauma, 2000, 17(8): 641 -647.
  • 5Beauddeux J, Dequen L, Foglietti M. Pathophysiologic aspects of S100B protein: a new biological marker of brain pathology. Ann Biol Clin (Paris), 1999, 57(3) :261 - 272.
  • 6Hu J, Ferreira A, Van Eldik LJ, et al. S100 beta induces neuronal cell death through nitric oxide release from astrocytes. J Neurochem, 1997,69(6):2294 - 2301.
  • 7Mcadory BS, Van Eldik LJ, Norden JJ, et al. S100B, a neurotrophic protein that modulates neuronal protein phosphorylation, is upregulated during lesion - induced collateral sprouting and reactive synaptogenesis.Brain Res, 1998, 813(2): 211-217.
  • 8Fano G, Biocca S, Fulie S, et al. The S100: a protein family in search of a function. Prog Neurobiol, 1995, 46(1):71-82.
  • 9Herrmann M, Jost S, Kutz S, et al. Temporal profile of release of neurobiochemical markers of brain damage after traumatic brain injury is associated with intracranial pathology as demonstrated in cranial computerized tomogryaphy. J Neurotruma, 2000, 17(2):113- 122.
  • 10Nygaard O, Langbakk B, Romner B. Age- and sex-related changes of S- 100 protein concentrations in cerebrospinal fluid and serum in patients with no previous history of neurological disorder. Clin Chem,1997, 43(3) :541 - 543.

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创伤外科杂志
2005年 第2期

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