恶性纤维组织细胞型骨肉瘤免疫组化及超微结构研究

Malignant Fibrous Histiocytoma Type of Os-teosarcolna

报道１０例恶性纤维组织细胞型（ＭＦＨ）骨肉瘤，用形态学、超微结构、酶及免疫组化方法进行研究。异形的梭形细胞，组织细胞样细胞和畸形的单核和多核巨细胞混合存在，常见不典型分裂象。席纹状排列和软骨岛分别见于３例。由于肿瘤性骨样和骨组织的存在可以区分骨的原发性ＭＦＨ和ＭＦＨ型骨肉瘤。肿瘤的梭形细胞、组织细胞和巨细胞碱性磷酸酶阳性，标记组织细胞Ｍａｃ－３８７阳性（分别见于所检测的３例），２例软骨岛Ｓ－１００阳性。

AbstractTen cases of malignant fibrous histiocytomatype of osteosarcoma were studied by morphologi-cal ultrastructural and enzyme and immunohis-tochemical methods,An admixture of AtypicalSpindle cells,histiocytic like cells and bizarremononucleated and muItlinucleated giant cells andatypical mitotic figures were common in all foci ofstofiform pettern and islands of cartilage were pre-sent in three cases,Morphologically,primaryMFH of bone can be distinguished from MFH typeof Osteosarcoma by the presence of neoplastic os-teoid or woren bone。 Tunor spindle cells,histio-cytes were positive for Mac-387 in three cases.