摘要
目的研究TGF-β1(转化生长因子-β1)基因多态性在广西瑶族与汉族人群中的分布。方法应用聚合酶链反应-限制性片段长度多态性技术检测150名瑶族人和190名汉族人的TGF-β1基因多态性,比较两组人群TGF-β1基因型和等位基因的分布频率。结果在瑶族人中CC基因型占46·0%、CT基因型占43·3%、TT基因型占10·7%;在汉族人中CC基因型占30·0%、CT基因型占51·1%、TT基因型占19·9%。两组人群TGF-β1基因型的分布频率差异有显著性(P<0·05)。结论瑶族与汉族人群TGF-β1基因多态性分布频率差异有显著性。
Objective:To study the difference between the Chinese Yao and Han ethnic groups in Guangxi province in the distribution of TGF-β_1 gene polymorphism. Methods:TGF-β_1 gene polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in Yans(n=150) and Hans(n=190). Results:The frequencies of CC, CT and TT genotypes were found to be 46.0%, 43.3% and 10.7% in the Yaos, and 30.0% , 51.1% and 19.9% in the Hans respectively. A significant difference was seen in the frequency distribution of TGF-β_1 genotype between the Yaos and the Hans (P<0.05). Conclusion:There were significant difference of TGF-β_1 gene polymorphism between the Yaos and the Hans.
出处
《中国优生与遗传杂志》
2005年第7期20-21,27,共3页
Chinese Journal of Birth Health & Heredity
基金
广西教育厅基金资助项目(桂科教200420)
