肾移植术后肺部感染84例患者预后的多因素Cox模型分析

Multivariate prognostic evaluation of pulmonary infection in 84 kidney transplantation patients using Cox proportion hazard model

目的:对影响肾移植术后肺部感染患者预后的相关因素进行评价.方法:回顾84例肾移植术后肺部感染患者的临床资料,统计PRA、免疫抑制方案、抗感染治疗方案等15项相关因素,应用Cox比例风险模型检验各因素与肺部感染患者生存时间的关系.结果:合并呼吸窘迫综合征(ARDS)、术后预防性应用更昔洛韦、应用OKT3及抗感染治疗方案是影响肾移植术后肺部感染患者预后的4个主要因素.各种口服免疫抑制剂方案对预后的影响无显著性差异.结论:应用Cox模型能够准确分析肾移植术后肺部感染患者的预后因素.ARDS、术后预防性应用更昔洛韦、应用OKT3及抗感染治疗方案是影响肾移植术后肺部感染患者预后的4个主要因素.

AIM: To evaluate the prognostic factors for pulmonary infection in kidney transplantation patients. METHODS: Eighty-four cases with pulmonary infection in kidney transplantation were studied and 15 factors such as panel reactive antibody (PRA), immunosuppression regimens and antimicrobial treatments were evaluated by Cox's proportional hazard index analysis to locate the significant factors related to prognosis. RESULTS: Acute respiratory disease syndrome (ARDS), preventive anti-CMV treatment, OKT3 and antimicrobial treatments were the four main factors. No significant difference was found in prognosis between various oral immunosuppression regimens. CONCLUSION: The prognosis of pulmonary infection in kidney transplantation patients can be accurately analyzed by Cox's proportional hazard model. ARDS, preventive anti-CMV treatment, OKT3 and antimicrobial treatments are the main factors related to the prognosis of pulmonary infection.