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人肝纤维化相关细胞的研究 被引量:7

Study on cells associated with human liver fibrosis
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摘要 应用免疫组化及核酸分子杂交技术研究人肝纤维化中与细胞外基质(ECM)沉积有关的细胞。结果显示慢性肝病组ECM均增高,尤其是活动性慢性肝病者III型胶原及其mRNA更为突出,该组III型胶原前肽(PIIIP)的免疫组化及原位杂交阳性细胞亦明显增多,主要位于间质与实质交接处。免疫组化及电镜证明这些胶原生成细胞主要是与贮脂细胞相关的间质细胞,其增生程度与炎症细胞浸润密切相关。 The cells which related to deposition of extracellular matrix( ECM)in human liver fibrogenesis were investigated with immunohistorhemistry(IHC )and nucleic acid hybridization。ResuIts showed that ECMs were high in chronic liver disease(CLD)tissues,particularly collagen III and its mRNA in active-CLD。In this group,cells positive for pre-collagen III pro-peptide(PIIIP)and collagen III mRNA were markedly increased and mostly located in the area connecting interstitium and parenchyma。hese collagen producing cells were mainly the interstitial cells identified by IHC and electron microscopy as fat storing cells and associated myofibroblasts and fibroblasts。Their degree of hyperplasia was closely relat-ed to the infiltration of inflammatory cells.
出处 《中华病理学杂志》 CAS CSCD 北大核心 1995年第3期159-161,共3页 Chinese Journal of Pathology
基金 国家自然科学基金 教委博士点基金
关键词 胶原 肝纤维化 细胞增生 Liver diseases Collagen Hyperplasia
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  • 1周侃,中国组织化学与细胞化学杂志,1994年,3卷,134页

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