摘要
目的:植物雌激素是植物中可以与雌激素受体结合的一类化合物,在体内具有双向调节作用,表现为选择性雌激素活性,既能产生雌激素样作用,又能产生抗雌激素样作用。资料来源:通过计算机检索Medline1988-01/2004-12期间关于蛇床子的植物雌激素样作用的文章,检索词为“osthole、Cnidiummonnieri(L)Cuss、phytoestrogen″并限定文章语言种类为″English″。同时检索万方数据库1988-01/2004-12期间关于蛇床子的植物雌激素样作用文章,检索词“蛇床子素、蛇床子、植物雌激素”,限定文章语言种类为中文。资料选择:纳入标准:对实验研究文献文章中随机、对照条件的限制;排除标准:对文献中重复研究、综述和Meta分析限制。资料提炼:共收集到45篇随机和未随机试验,32项试验符合纳入标准。排除的13篇试验中,9篇因系重复的同一研究,2篇为Meta分析研究,2篇为综述。资料综合:32篇文献中分别对应用蛇床子及其提取物方案予以评价。蛇床子的药理作用广泛,在抗氧化、抗肿瘤和对心血管疾病和绝经期骨质疏松症的治疗等具有潜在的开发应用价值。结论:蛇床子的植物雌激素样作用不仅表现其性激素样作用,也表现为钙拮抗作用、抗氧化作用、抗细胞凋亡作用。它对激素相关疾病如骨质疏松症、心血管疾病和肿瘤等有广泛作用,同时可能在中枢发挥保护作用,尤其是可能预防和治疗老年性痴呆疾病。
OBJECTIVE: Phytoestrogen is a kind of compound in plants that can combine with estrogen receptor, and it plays a role of bilateral adjusting in vivo, which is manifested by the activity of selective estrogen, it can produce both estrogen-like effect and anti-estrogen-like effect. DATA SOURCES: An online search was undertaken to identify the articles about the phytoestrogen-like effect of Cnidium monnieri(L) cuss published in English from January 1988 to December 2004 by using the of ″osthole, Cnidium monnieri (L) cuss, phytoestrogen″; Meanwhile, Chinese articles about the phytoestrogen-like effect of Cnidium monnieri(L) cuss between January 1988 to December 2004 were searched in Wanfang database, the keywords were ″osthole, Cnidium monnieri (L) cuss, phytoestrogen″. STUDY SELECTION: Inclusion criteria: Randomized control study; Exclusion criteria: repetitive studies, review and Meta analysis. DATA EXTRACTION: Totally 45 randomized and non-randomized trials were collected, and 32 were in accordance with the inclusion criteria; Among the 13 excluded trials, 9 were repetitive, 2 were Meta analysis and 2 were reviews. DATA SYNTHESIS: The 32 articles evaluated the application program of Cnidium monnieri (L) cuss and its extracts. The pharmacological effects of Cnidium monnieri (L) cuss was versatile. It was predicted that Cnidium monnieri(L) cuss and its extracts had potential values of application and development in the effects of anti-oxidation and anti-tumor, also in treating cardiovascular diseases and menopausal osteoporosis. CONCLUSION: The phytoestrogen-like effect of Cnidium monnieri(L) cuss is manifested not only by its sex hormone-like effect, but also by its roles of calcium antagonist, anti-oxidation and anti-apoptosis. It has extensive effects on hormone related diseases, such as osteoporosis, cardiovascular diseases and tumor; And it possibly plays a role in protecting central nervous system, especially may prevent and treat Alzheimer disease.
出处
《中国临床康复》
CSCD
北大核心
2005年第23期186-189,共4页
Chinese Journal of Clinical Rehabilitation
基金
江西省自然科学基金资助项目(95502)~~